The objective of this study is to determine if a single spinal shot of morphine can decrease post-operative opioid-use, and thereby decrease opioid side-effects and lead to a quicker recovery after surgery.
We expect that in laparoscopic gastro-intestinal surgery, a single shot spinal with bupicavaine/morphine will result in a better analgesia in hte first 48 hours. Herby the patients will require less systemic opioids, which will decrease the side-effects. Furthermore, we expect the patients to recover quicker and show an earlier mobilisation and a shorter hospital stay. The objective of this study is to determine if a single spinal shot of morphine can decrease post-operative opioid-use, and thereby decrease opioid side-effects and lead to a quicker recovery after surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
56
Spinal injection bupivacaine/morphine in laparoscopic surgery
placebo injection
Maasstad Hospital
Rotterdam, Netherlands
Duration of hospital stay
Time frame: first 48 hours
use of piritramide by PCIA-pump in mg
Time frame: 48 hours
patient-satisfactory on a 4-point scale
Time frame: 120 hours/ 5 days
the occurence of side-effects (nausea, pruritus, drowsiness)
Time frame: 120 hours/ 5 days
time to mobilisation
Time frame: 120 hours/ 5 days
time to bowel movement
Time frame: 120 hours/ 5 days
abdominal compliance during laparoscopy in L/mmHg
Time frame: The compliance will be measured for the duration of the surgery, an expected average of 2 hours.
Difficulty of surgery
Time frame: The difficulty of surgery will be measured for the duration of the surgery, an expected average of 2 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.