A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)

Inclusion Criteria: * Patient-reported history of Dry Eye Disease in both eyes. * Use of over the counter artificial tears within the past 30 days. * A negative urine pregnancy test for females and willingness to use adequate birth control throughout the study. * Able and willing to comply with all study procedures. Exclusion Criteria: * Presence of an ocular condition that could affect the study parameters such as active ocular infections, ocular inflammation, glaucoma, or diabetic retinopathy;. * Unwilling to stop wearing contact lenses during the study. * LASIK or other ocular surgical procedures within 12 months prior to or during the study. * Use of prohibited medications * Significant medical conditions that could affect the study parameters.