The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway

Ajou University School of Medicine39 enrolled

Overview

Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough amount. Dexmedetomidine is a selective alplh2 receptor agonist with analgesic and sedative effects but sparing respiratory function. Therefore propofol combined with dexmedetomidine induction could be more effective in preserve respiration under same condition for LMA insertion than propofol alone. In this study, the investigators investigate the clinical dose of propofol for LMA insertion with premedication of dexmedetomidine, and evaluate the effect of dexmedetomidine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Precedex Effect to Propofol Requirement

Interventions

Dexmedetomidine

Eligibility

Sex: ALLMin age: 19 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients for surgery not exceed more than 2 hours requiring general anesthesia Exclusion Criteria: * history of gastroesophageal reflux High grade obesity Predicted diffiicult airway

Outcomes

Primary Outcomes

Fail or success for Laryngeal Mask Airway (LMA) insertion

Failure for LMA insertion is defined if there is a difficulty for mouth opening or active movement of four limbs or head. Success is smooth LMA insertion without any movement

Time frame: During inserting LMA and up to 5 seconds after LMA inserion