Two-stent vs Provisional Stenting Techniques for Patients With Complex Coronary Bifurcation Lesions

Inclusion Criteria: * Provision of informed consent prior to any study specific procedures; * Men and women 18 years and older;. * Established indication to PCI according to the guidelines of American Heart Association and American College of Cardiology; * Native coronary lesion suitable for drug-eluting stent placement; * True bifurcation lesions (Medina 0,1,1/1,1,1); * Reference vessel diameter in side branch ≥2.5mm by visual estimation; * Complex bifurcation lesions based on DEFINITION study. Exclusion Criteria: * Pregnancy and breast feeding mother; * Co-morbidity with an estimated life expectancy of \< 50 % at 12 months; * Scheduled major surgery in the next 12 months; * Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; * Unable to provide written informed consent, or fail to follow the protocol; * Previous enrolment in coronary intervention device investigation during the study period; * Patient with STEMI within 24-hour from the onset of chest pain to admission; * Restenosis bifurcation lesions.