The Minimum Effective Concentration of Ropivacaine in Ultrasound-guided Supraclavicular Block

Huazhong University of Science and Technology102 enrolled

Overview

The aim of this study is to determine the minimum effective concentration of local anesthetic (ropivacaine 40mL) required to produce an effective double-injection USG-SCB for surgical anesthesia in 90% of patients (MEC90) in young group (18-40 years) and in middle aged group (40-65 years) of patients scheduled for elective surgery of one upper limb distal to the shoulder.

The study is based on biased coin design, and the concentration of LA for the next patient is determined by the result of the last one. In the case of block failure, the concentration will be increased by 0.025%. Conversely, block success will result in either a reduction in concentration by 0.025% (probability 11%) or no change in concentration (probability 89%). A blinded assistant will assess sensory and motor blockade in each nerve territory ( the median, radial, ulnar and musculocutaneous nerves) at 10-min intervals up to 30 min after completion of the block. Finally, MEC90 is calculated by isotonic regression.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

102

Conditions

Minimum Effective Concentration of Local Anesthetic

Interventions

brachial plexus blockOTHER

brachial plexus block with ropivacaine 40ml

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. age between 18 and 65 years 2. ASA 1-3 3. body mass index between 18 and 35kg/m2 Exclusion Criteria: 1. inability to consent to the study 2. pregnancy 3. allergy to local anesthetics 4. preexisting neuropathy or coagulopathy 5. prior surgery in the supraclavicular region

Locations (1)

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Outcomes

Primary Outcomes

The Minimum Effective Concentration of Ropivacaine in Ultrasound-guided Supraclavicular Block

The Minimum Effective Concentration (MEC) of Ropivacaine in Ultrasound-guided Supraclavicular Block is based on 60 measurements in 60 patients (secondary outcome measure: block success). MEC is determined by biased coin design method when all patients have been tested in the study.

Time frame: up to 6 months

Secondary Outcomes

Block success

A blinded Assistant assess the sensory and motor block onset time for each nerve (median, radial, ulnar and musculocutaneous) at 10-min intervals up to 30 min after completion of the block.

Time frame: up to 30 minutes after nerve block is performed

Data from ClinicalTrials.gov

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