This prospective randomized controlled trial was conducted To compare the efficacy of TNA in terms of total blood loss and the allogenic transfusion rate among the three study groups; intravenous alone, combined intravenous and low dose topical TNA and combined intravenous and high dose topical TNA. To evaluate the safety of each regimen in view of deep vein thrombosis and venous thromboembolism.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
264
Change in Hemoglobin
Blood loss reduce
Time frame: baseline and 5 days
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