The purpose of this pilot study is to determine the effect of transcranial direct current stimulation (tDCS) on brain activity and fine motor skills in patients with Parkinson's disease compared to healthy controls.
The pilot study will involve a double-blind, sham controlled cross-over design where participants will receive anodal and sham tDCS stimulation in a randomized order. Differences in brain activity and fine motor skill performance between groups and after tDCS stimulation will be compared.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
CatholicULeuven
Leuven, Belgium
Change in writing amplitude
Centimeter (cm)
Time frame: post-stimulation (immediately after) and retention (1 week)
Change in writing velocity
Centimeter per second (cm/s)
Time frame: post-stimulation (immediately after) and retention (1 week)
Change in speed on the Purdue Pegboard task
Number of pegs placed in 30 seconds
Time frame: post-stimulation (immediately after) and retention (1 week)
Change in cortical excitability
Motor Evoked Potentials (MEP) peak to peak amplitude and latency - Measured with single-pulse Transcranial Magnetic
Time frame: post-stimulation (immediately after) and retention (1 week)
Change in Short-Latency Intracortical Inhibition (SICI)
Measured with double-pulse Transcranial Magnetic Stimulation (TMS)
Time frame: post-stimulation (immediately after) and retention (1 week)
Change in cortical silent period (cSP)
Measured with single-pulse Transcranial Magnetic
Time frame: post-stimulation (immediately after) and retention (1 week)
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