The Effect of BIA 2-093 on the Steady-state Pharmacodynamic and Pharmacokinetic Profiles of Warfarin

Inclusion Criteria: * Male or female subjects aged between 18 and 45 years, inclusive * Subjects of body mass index (BMI) between 19 and 28 kg/m2, inclusive * Subjects who were healthy as determined by pre-study medical history, physical examination, neurological examination, and 12-lead ECG * Subjects who had clinical laboratory tests clinically acceptable * Subjects who were negative for HBs Ag, anti-HCV Ab and anti-HIV-1 and HIV-2 Ab tests at screening * Subjects who were negative for alcohol and drugs of abuse at screening * Subjects who were non-smokers or who smoked less than 10 cigarettes or equivalent per day * Subjects who were able and willing to give written informed consent * In case of female volunteers, subjects who were not of childbearing potential by reason of surgery or, if of childbearing potential, used one of the following methods of contraception: double-barrier or intrauterine device * In case of female volunteers, subjects who had a negative pregnancy test at screening Exclusion Criteria: * Subjects who did not conform to the above inclusion criteria * Subjects who had a clinically relevant history or presence of respiratory gastrointestinal, renal, hepatic, haematological, lymphatic, neurological cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological dermatological, endocrine, connective tissue diseases or disorders * Subjects who had a current haemostatic disorder or a personal or family history of any such disorder * Subjects who had a personal or family history of bleeding complications after surgery or tooth extraction, nose or gingival bleeding, or haemorrhagic diathesis. * Subjects with a profession or activities implying a special risk of trauma * Subjects with any abnormality in the coagulation status (aPTT or prothrombin INR) * Subjects who had a clinically relevant surgical history * Subjects who had a clinically relevant family history * Subjects who had a history of relevant atopy * Subjects who had a history of relevant drug hypersensitivity * Subjects who had a history of alcoholism or drug abuse * Subjects who consumed more than 14 units of alcohol a week * Subjects who had a significant infection or known inflammatory process on screening and/or admission * Subjects who had acute gastrointestinal symptoms at the time of screening and/or admission (e.g., nausea, vomiting, diarrhoea, heartburn) * Subjects who had used prescription drugs within 2 weeks prior admission on Phase A * Subjects who had used any investigational drug and/or participated in any clinical trial within 2 months prior admission to Phase A * Subjects who had previously received BIA 2-093 * Subjects who had donated and/or received any blood or blood products within the previous 2 months prior admission to Phase A * Subjects who were vegetarians, vegans and/or had medical dietary restrictions * Subjects who could not communicate reliably with the investigator