Efficacy and Safety of Domestic Tenofovir Tablets in Chinese Patients With Chronic Hepatitis B

Inclusion Criteria: * The initial treatment of subjects diagnosed of HBeAg positive or negative chronic hepatitis B * Aged 18 to 65 years old，male or female * Patients with previously HBsAg-positive lasted for 6months at least：HBeAg-positive subjects, HBV-DNA\> 105copies/ml； HBeAg-negative subjects, HBV-DNA\> 104copies/ml. * 2 times the upper normal limit (2 × ULN) ≤ alanine aminotransferase (ALT) ≤ 10 × ULN. * Total serum bilirubin (TBIL) ≤ 2.5 × ULN. * Prothrombin activity (PTA) ≥ 60% or prothrombin time prolonged than normal ≤ 3 seconds). * WBC ≥ 3.5 × 109 / L, PLT ≥ 80 × 109 / L, serum albumin (ALB)≥ 35 g / L. * Creatinine (Cr) ≤ 1× ULN，serum phosphate was normal. * Patients signed an informed consent form and compliance was good. Exclusion Criteria: * Patients were infected with other viruses as HAV, HCV, HEV, HIV etc. * Patients with cirrhosis or liver cancer. * Pregnant woman, lactating women . * Patients with severe heart, kidney, endocrine hematopoietic system and neuropsychiatric diseases. * Patients with metabolic or autoimmune diseases such as systemic lupus erythematosus. * Patients allergic for study drug.