Clinical Trial I/II Opened, Randomized and Controlled for the Study of the Use of Stem Cells Therapy in Insulinized Diabetic Patients Type 2 With Critical Ischemia in Lower Limbs (CLI): Study of the Needs of Insulin

Inclusion Criteria: 1. Age ≥18 and ≤ 85 years 2. Diabetic type 2, in treatment with insulin at least 3 previous months. 3. Vascular disease infrapopliteal atherosclerotic of severe degree (Patients with category Rutherford-Becker ≥ 4), pretty or bilateral. The critical ischemia of the foot is defined as a persistent / persistent pain that needs analgesia and / or not healing present sores\> 4 weeks, without evidence of improvement with conventional therapies and / or walking test between 1-6 minutes in two ergometries separated at least for 2 weeks and / or index ankle - arm in rest \<0,8. 4. Impossibility of revascularization surgical or endovascular or I fail in the surgery of revascularization performed at least 30 days before, with persistence or entry in phase of critical ischemia 5. Life expectancy \> 2 years. 6. Major amputation is not foreseen in any of the members in the next 6 months after the incorporation. 7. Normal Biochemical and bone marrow parameters defined for: * Leukocytes ≥ 3000 * Neutrophils ≥ 1500 * Platelets ≥ 140000 * AST/ALT ≤ 2,5 standard range institution * Creatinine ≤2,5 mg/dl and explanation of creatinine ≤ 30 ml/min (MDRD4) 8. The women in fertile age will have to obtain negative results in a pregnancy test realized in the moment of the incorporation in the study and promise to use a contraceptive method medically approved while the study lasts. 9. Patients who give his Informed Consent in writing for the participation in the study. 10. Patients who have not taken part in another clinical trial in the last 3 months before the incorporation. Exclusion Criteria: 1. Precedent of neoplasia or hematologic disease (disease myeloproliferative, syndrome myelodysplasic or leukaemia) in the last 2 years. 2. Major previous amputation. 3. Patients with arterial uncontrolled hypertension (defined as arterial tension\> 180/110 in more than one occasion). 4. Cardiac severe insufficiency (NYHA the IVth) or Fraction of Ejection of left ventricle (FAITH) lower than 30 %. 5. Patients with ventricular malignant arrhythmias or unstable angina. 6. Diagnosis of venous deep thrombosis in 3 previous months. 7. Patients with genotype DD of the ECA or genotype E4 of the apo E. 8. Concomitant therapy that includes oxygen hyperbaric, vasoactive substances, agents against angiogenesis or inhibiting Cox-II. The agents use is allowed antiplatelets. 9. Index of corporal mass\> 40 Kg/m2. 10. Patients with the diagnosis of alcoholism in the moment of the incorporation. 11. Proliferative Retinopathy without possibility of treatment. 12. Diabetic Nephropathy with haemodialysis 13. Concomitant disease that reduces the life expectancy to less than 1 years. 14. Impossibility foreseen to obtain the inhaled one of 100ml of bone marrow. 15. Infection for HIV, Hepatitis B or Hepatitis C. 16. Impede in the follow-up. 17. ACV or heart attack of myocardium in the last 3 months 18. Anaemia (Haemoglobin \<7.9 g/dl) 19. Patients before treated with cellular therapy.