Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study

Inclusion Criteria: * Signs of hypoperfusion: serum lactate \>2 mmol/L, low central venous oxygen saturation (ScvO2) (\<70%) or high ScvO2 (\>85%), metabolic acidosis, oligo-anuria, high venous-to-arterial CO2-gap (dCO2 \>6 mm Hg) * Hemodynamic support with vasopressors * Procalcitonin level ≥ 3 ng/ml * Invasive hemodynamic monitoring * Written informed content Exclusion Criteria: * Patients under 18 years * Pregnancy (bHCG test positivity) * Surgical intervention in context with the septic insult * New York Heart Association IV heart failure * Acute coronary syndrome * Need for acute or chronic hemodialysis * Acute haematological malignancies * Cardiogenic shock * Post cardiopulmonary resuscitation care * Immunosuppression, systemic steroid therapy (\>10mg prednisolon/day) * Human immunodeficiency virus infection (HIV) and active AIDS * Patients with donated organs * Thrombocytopenia (\<20.000/ml) * More than 10%-of body surface area with third degree burn