A Clinical Trial on the Candidate Vaccine cAd3-EBOZ in Healthy Adults in Switzerland

Inclusion Criteria: 1. Healthy adults aged 18 to 65 years 2. Able and willing (in the Investigator's opinion) to comply with all study requirements 3. Willing to allow the investigators to discuss the volunteer's medical history with their general practitioner 4. For females of reproductive capacity and males, having practiced continuous effective contraception for 21 days prior to enrolment, and willing to practice continuous effective contraception for 3 months post vaccination 5. For females of reproductive capacity, having a negative pregnancy test on the day(s) of screening and vaccination if \>7 days interval 6. Agreement to refrain from blood donation during the course of the study 7. Provide written informed consent Exclusion Criteria: 1. Participation in another research study involving receipt of an investigational product in the 30 days preceding enrolment, or planned use during the study period 2. Prior receipt of an investigational Ebola or Marburg vaccine or a chimpanzee adenovirus vectored vaccine 3. Receipt of any live, attenuated vaccine within 28 days prior to enrolment 4. Receipt of any subunit or killed vaccine within 14 days prior to enrolment (influenza vaccination is encouraged prior to participation) 5. Receipt of any investigational vaccine within 3 months prior to enrollment 6. Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate 7. Any confirmed or suspected immunosuppressed or immunodeficient state, including HIV infection; asplenia; recurrent, severe infections and chronic (more than 14 days) immunosuppressive medication within the past 6 months (inhaled and topical steroids are allowed) 8. History of allergic reactions likely to be exacerbated by any component of the vaccine, 9. Any history of hereditary angioedema, acquired angioedema, or idiopathic angioedema. 10. Any history of anaphylaxis in reaction to vaccination 11. Pregnancy, lactation or willingness/intention to become pregnant during the study 12. History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) 13. History of serious psychiatric condition 14. Poorly controlled asthma or thyroid disease 15. Seizure in the past 3 years or treatment for seizure disorder in the past 3 years 16. Bleeding disorder (eg. Factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following intramuscular injections or venepuncture 17. Any other serious chronic illness requiring hospital specialist supervision 18. Current anti-tuberculosis prophylaxis or therapy 19. Suspected or known current alcohol abuse 20. Suspected or known injecting drug abuse in the 5 years preceding enrolment 21. Seropositive for hepatitis B surface antigen (HBsAg) 22. Seropositive for hepatitis C virus (antibodies to HCV) 23. Any clinically significant abnormal finding on screening biochemistry or haematology blood tests or urinalysis 24. Any other significant disease, disorder or finding which may significantly increase the risk to the volunteer because of participation in the study, affect the ability of the volunteer to participate in the study or impair interpretation of the study data