Prevalence and Topography of Adenomas in 40-49 Year Old Patients With a Family History of Colon Cancer

Inclusion Criteria: * 40-49 year old asymptomatic men and women referred for colorectal cancer screening with a family history of CRC in a first degree relative; * 40-49 year old asymptomatic men and women referred for colorectal cancer screening with a family history of polyps in a first degree relative; * 40-49 year old men and women without a family history of CRC or polyps in a first degree relative who are referred for colonoscopy to evaluate scant hematochezia characterized as red blood on toilet tissue after wiping or small droplets of blood on stool or in toilet water after evacuating stool, abdominal discomfort or altered bowel habits characterized as constipation or diarrhea. Exclusion Criteria: * Personal history of iron deficiency anemia within six months of referral; * Personal history of iron deficiency without anemia within six months of referral; * Personal history of (+) FOBT within one year of referral; * Personal history of previous colonoscopy or barium enema within the past 10 years; * Personal history of previous flexible sigmoidoscopy in the past 5 years; * Personal history of adenoma, colorectal cancer, inflammatory bowel disease, HNPCC, or familial adenomatous polyposis (FAP); * Unintentional weight loss \> 10 lbs within the previous six months; * Individuals with family history of CRC AND scant hematochezia; * Inability to speak and read English.