The investigators want to evaluate the effects and safety of ginger in treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Ginger (Zingiber officinale Roscoe) has been cultivated for medicinal and culinary purposes for at least two millennia. It contains several hundred valuable compounds and new constituents are still being found. Ginger's high antioxidant value has proved highly effective with its ability to scavenge a number of free radicals and protect cell membrane lipids from oxidation in a dose-dependent manner. In a randomized double-blind placebo-controlled clinical trial, the investigators want to investigate the effects of ginger in treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
76
Shahid Motahhari Clinic, Shiraz University of Medical Sciences
Shiraz, Fars, Iran
Change in ALT (liver transaminases) level
Change in the concentration of ALT (liver transaminases)
Time frame: Baseline and 3 months
Change in score of fatty liver in fibroscan
Change in score of fatty liver in fibroscan (elastography)
Time frame: Baseline and 3 months
Change in AST (liver transaminases) level
Change in the concentration of AST (liver transaminases)
Time frame: Baseline and 3 months
Change in Gama GT (γ-glutamyl transpeptidase) levels
Change in the concentration of Gama GT (γ-glutamyl transpeptidase)
Time frame: Baseline and 3 months
Number of patients with adverse events
Number of patients with adverse events
Time frame: 4 months
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