The success of colonoscopy is closely related to the quality of colonic preparation. However, data regarding colonoscopy preparations in the elderly (65 years older) are scarce. Split-dosage cathartic bowel preparation are currently suggested, whereas supporting evidence is lacking in this particular group of patients. Moreover, patient tolerability is a key factor for success of bowel preparation in the aged people. The purpose of this study is to compare the bowel cleansing efficacy and patient compliance of following bowel preparation methods prior to elective outpatient colonoscopy in the elderly: (1) standard preparation of 4 liters (L) PEG-3350 solution on the night before colonoscopy, (2) split-dose of 4L PEG-3350 solution, and (3) split-dose of reduced volume \[2L\] PEG-3350 containing ascorbic acid solution.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
230
Subjects will be asked to take 4L of PEG-3350 solution the day prior to procedure.
Subjects will be asked to take 2L of PEG-3350 solution the day prior to procedure, followed by another 2L of PEG-3350 solution on the day of the procedure.
Subjects will be asked to take 1L of PEG-3350 containing ascorbic acid solution the day prior to procedure, followed by another 1L of PEG-3350 containing ascorbic acid solution on the day of the procedure.
Hanyang University Guri Hospital
Guri-si, South Korea
Kangbuk Samsung Hospital
Seoul, South Korea
Kyung Hee University Hospital
Seoul, South Korea
Proportion of adequate bowel preparation quality at the time of colonoscopy defined by the Boston bowel preparation scale (BBPS).
The BBPS assesses cleanliness of 3 segments of the colon (ascending, transverse, and descending colon), and the total is a 10-point scale (0-9) that grades each segment of the colon from 0 to 3. In this study, adequate bowel preparation is defined as a total score 6 points or higher and individual score of 2 points or higher in each segment.
Time frame: 1 year
Patient satisfaction with recommended bowel preparation method based on the 10-point visual analog scale
Time frame: 1 year
Rate of adverse events related to bowel preparation for colonoscopy
Adverse events include tenesmus, sleep disturbance, nausea, vomiting, abdominal cramping, abdominal fullness, abdominal discomfort, headache, dizziness, and others.
Time frame: 1 year
Number of patients who have a willingness to repeat same bowel preparation method method
Time frame: 1 year
Consumed volume of recommended bowel preparation agent based on the 3-grade scale
The 3-grade scale: optimal (100%), good (≥ 75%), and poor (\< 75%)
Time frame: 1 year
Difficulty of completing ingestion of recommended bowel preparation agent based on the 3-grade scale
The 3-grade scale: never, some, and much
Time frame: 1 year
Taste of recommended bowel preparation agent based on the 3-grade scale
The 3-grade scale: bad, neutral, and good
Time frame: 1 year
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