The investigator will determine a compliance of two diagnostic techniques (EIT and Body plethysmography) in collective of children and teenagers with obstructive lung disease and a matched control group.
The aim of the present study is verification of the correlation between EIT-derived data and following extracted parameters of the pulmonary function: * forced expiratory volume in 1 second (FEV 1) * forced vital capacity (FVC) * relative forced expiratory volume in 1 second (FEV1/FVC) * maximal expiratory flow (MEF 25) * total lung capacity (TLC) * resistance (Raw). These findings could bring out new prospective opportunity for pulmonary function tests without cooperation. Furthermore, the study aims to clarify whether EIT technique can be used for regional pulmonary function testing. In addition, dynamic lung function parameter and static radiological techniques will be correlated with EIT.
Study Type
OBSERVATIONAL
Enrollment
192
The 16-electrode belt will be applied to patient's chest. Following vital signs will be recorded: respiratory rate at rest breathing, heart rate, transcutaneous oxygen saturation. Then impulse oscillometry (IOS) will be performed in a sitting position. After that, subjects with cooperation willingness will get a body plethysmography. A spirometry / forced breathing maneuvers will be performed. All patients will receive 2 strokes salbutamol inhaler for bronchospasmolysis. Please note that inhalation of salbutamol is not study related. It is used in the clinical routine to examine the reversibility of the bronchial obstruction in patients with obstructive lung disease in course of the lung function test. Ten minutes later measurements described above will be repeated.
Probands will receive the same treatment as patients, but without bronchospasmolysis.
University Hospital Aachen
Aachen, North Rhine-Westphalia, Germany
Robustness of change in electrical impedance based on the forced expiratory volume in 1 second (ΔZFEV01)
The robustness of ΔZFEV1.0 (= change in electrical impedance based on the FVC FEV1.0) and τ (= mechanical time constant τ which classifies the regional and global lung mechanics) and their clinical relevance will be investigated.
Time frame: Baseline
Correlation between lung function parameters and extracted parameters of the EIT.
The present study aims to verify, whether a correlation between lung function parameters and extracted parameters of the EIT exists.
Time frame: Baseline
EIT as a diagnostic method for assessment of lung function
It will be examined, whether single EIT measurement can be used for assessment of the lung function.
Time frame: Baseline
Regional mechanical transmission behavior
Another secondary outcome is the local mechanical transmission behavior as an index of pulmonary status. By using the correlation between results gained from EIT and results from impulse oscillometry (IOS) differentiation between central and peripheral obstruction of respiratory tracts will be proved.
Time frame: Baseline
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