Feasibility Study Using Run-to-Run Control to Optimize Continuous Glucose Sensor Bias

Inclusion Criteria: * Clinical diagnosis of type 1 diabetes for at least one year. * The diagnosis of type 1 diabetes is based on the investigator's judgment; C peptide level and antibody determinations are not needed. * Actively using an insulin pump (CSII therapy) for the last 6 months, and will continue to use an insulin pump throughout the trial. * Age 18 to 75 years. * For females, not currently known to be pregnant or nursing. * HbA1c \< 9.5%, as measured with DCA2000 or equivalent device. * Willing to perform the calibration of the study CGMs using a finger stick only and willing to follow instructions for CGM wear. * Able to and agrees to avoid the following medication starting 24 hours before sensor wear through completion of the study: acetaminophen, prednisone. * An understanding of and willingness to follow the protocol and sign the informed consent. Exclusion Criteria: * Pregnancy (as determined by a positive blood pregnancy test performed in females of childbearing capacity during screening visit and before phase II) or nursing mother. * Diabetic ketoacidosis in the past 6 months prior to enrollment requiring emergency room visit or hospitalization. * Severe hypoglycemia resulting in seizure or loss of consciousness in the 6 months prior to enrollment. * Current treatment for a seizure disorder: Subjects with a history of seizures may be included in the study if they receive written clearance from their neurologist. * A known medical condition that in the judgment of the investigator might interfere with the completion of the protocol such as cognitive deficit. * Mental incapacity, unwillingness or language barriers precluding adequate understanding or co-operation, including subjects not able to read or write. * Active coronary artery disease or heart failure * Active gastroparesis * If on antihypertensive, thyroid, anti-depressant or lipid lowering medication, lack of stability on the medication for the past 2 months prior to enrollment in the study. * Uncontrolled thyroid disease: Adequately treated thyroid disease and celiac disease do not exclude subjects from enrollment. * Abuse of alcohol. * A recent injury to body or limb, muscular disorder, use of any medication, any carcinogenic disease, or other significant medical disorder if that injury, medication or disease in the judgment of the investigator will affect the completion of the protocol. * Current use of a beta blocker medication. * Laboratory results: * Hematocrit \< 30% or \>55%. * A1C ≥ 9.5% * Abnormal liver or renal function (Transaminase \>2 times the upper limit of normal, Creatinine\> 1.5 mg/dL) * Labs drawn at screening visit or within two months prior to screening (for other purposes) will suffice for enrollment purposes. * Subject has skin conditions that, in the determination of the investigator, would preclude wearing the study devices (CGM sensor), in the abdomen or upper buttocks. Examples include but are not limited to: psoriasis, burns, scaring, eczema, tattoos, and significant hypertrophy at sites of device wear; any known allergy to medical adhesives. * Current participation in another investigational trial or has previously participated in this study. However, for this study, if the augmented calibration algorithm is modified or more data is needed to update the calibration algorithm, subjects will be allowed to re-consent for additional studies at the judgment of the investigator. Similarly, if there is missing data from the data collection due to device failure, transmission errors or other problems, the subject will be allowed to extend the time required to continue each phase as per the judgment of the investigator and will not be excluded from continuing the study.