This is a randomized controlled trial to develop and test the efficacy of a multi-domain lifestyle behavioral intervention designed to promote healthier lifestyle behaviors linked to lower Alzheimer's disease risk among persons aged 40 to 64 years.
This is a randomized controlled trial to develop and test the efficacy of a multi-domain lifestyle behavioral intervention designed to promote healthier lifestyle behaviors linked to lower Alzheimer's disease risk among persons aged 40 to 64 years. Participants are randomized to treatment or control condition. The intervention, spanning a six month period, is an evidence-based health education program.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
146
The intervention is a health education program including: informational website, experiential classes, custom smart phone or smart table application, wearable activity monitor, and informal coaching by student researchers to provide moral support for lifestyle behavioral change goals. Participants are not placed on any specific behavioral regimen but instead are encouraged to adopt healthier lifestyle behaviors per the evidence-based health education program, and to attend the experiential classes "cafeteria style" (i.e. based on their individual preferences).
Picture Vocabulary
Picture Vocabulary cognitive test score
Time frame: up to 7 months
Flanker Inhibitory Control and Attention Test
Flanker Inhibitory Control and Attention Test cognitive test score
Time frame: up to 7 months
List Sorting Working Memory Test
List Sorting Working Memory Test cognitive test score
Time frame: up to 7 months
Oral Symbol Digit Test
Oral Symbol Digit Test cognitive test score
Time frame: up to 7 months
Montreal Cognitive Assessment
Montreal Cognitive Assessment test score
Time frame: up to 7 months
Rey Auditory Verbal Learning Test
Rey Auditory Verbal Learning Test score
Time frame: up to 7 months
Controlled Oral Word Association Test
Controlled Oral Word Association Test score
Time frame: up to 7 months
Blood pressure
Systolic and diastolic blood pressure
Time frame: up to 7 months
Body mass index
Height and weight measurement for computing body mass index
Time frame: up to 7 months
Insulin
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insulin from venipuncture blood sample
Time frame: up to 7 months
Systemic inflammation
C-reactive protein from venipuncture blood sample
Time frame: up to 7 months
Skin carotenoid status
Biophotonic device that shines a light-emitting diode (LED) light at a site on the palm, to measure the skin carotenoid level in units of Raman counts
Time frame: up to 7 months
Triglycerides
triglycerides from venipuncture blood sample
Time frame: up to 7 months
HDL Cholesterol
High-density lipoprotein from venipuncture blood sample
Time frame: up to 7 months
LDL Cholesterol
Low-density lipoprotein from venipuncture blood sample
Time frame: up to 7 months
Total cholesterol
Total cholesterol from venipuncture blood sample
Time frame: up to 7 months
Depression
Center for Epidemiologic Studies - Depression scale score
Time frame: up to 7 months
Motivation
Situational Motivation Scale score
Time frame: up to 7 months
Sleep Quality
Pittsburgh Sleep Quality Index scale score
Time frame: up to 7 months
Stress
Perceived Stress Scale score
Time frame: up to 7 months
Emotional Support
Emotional Support subscale from the NIH Toolbox measures for social engagement
Time frame: up to 7 months
Friendship
Friendship subscale from the NIH Toolbox measures for social engagement
Time frame: up to 7 months
Hostility
Hostility subscale from the NIH Toolbox measures for social engagement
Time frame: up to 7 months
Loneliness
Loneliness subscale from the NIH Toolbox measures for social engagement
Time frame: up to 7 months
Physical Activity - Moderate
self-report question concerning # minutes per day doing moderate intensity physical activity (per Center for Disease Control definition)
Time frame: up to 7 months
Physical Activity - Vigorous
self-report question concerning # minutes per day doing vigorous intensity physical activity (per Center for Disease Control definition)
Time frame: up to 7 months
Nutrition
Diet History Questionnaire
Time frame: up to 7 months
Readiness for Change
Revised University of Rhode Island Change Assessment (R-URICA) readiness for change scale
Time frame: up to 7 months
Metacognition
Total score from a set of seven items (1=much worse to 5=much better), comparing current memory to how it was three years ago, adapted from a questionnaire of functional ability
Time frame: up to 7 months