A Phase Ⅱ Study of XELOX Chemotherapy With or Without Surgery of Primary Lesion for Colon Cancer Patients

Inclusion Criteria: 1. 18\~75 ears old 2. Pathological diagnosis of colon cancer adenocarcinoma 3. No systemic chemotherapy for metastatic tumors 4. ECOG (Eastern Cooperative Oncology Group) 0-1 and expected survival period for 6 months or more 5. At least one measurable objective tumor lesions 6. ANC≥1.5\*109/L；PLT≥90\*109/L；HB≥90g/L；TBI≤1.5(UNL); ALT、AST≤2.5ULN；Cr≤1.0(ULN) screening within 7 days 7. Primary and metastatic tumors exist at the same time, and distant metastases are not resectable 8. Patients with voluntary participation, and sign the informed consent Exclusion Criteria: 1. Operation intervention required for perforation, bleeding and obstruction of intestinal cavity 2. With uncontrollable large pleural or peritoneal effusion 3. Alcohol or drug addictions 4. Malignant tumour of the past five years with other organizations to source, but the full treatment of cervical carcinoma in situ and except skin basal cell carcinoma and squamous cell carcinomas 5. With brain metastasis 6. Multiple primary colorectal carcinoma 7. Pregnancy or breast-feeding women 8. There is an important organ failure or other serious diseases, including coronary artery disease, symptomatic cardiovascular disease or myocardial infarction within 12 months; serious neurological or psychiatric history; severe infection; actively disseminated vascula blood coagulation.