Treatment of Chronic Graft-Versus-Host Disease With Mesenchymal Stromal Cells

Inclusion Criteria: * Newly diagnosed cGvHD * Informed consent obtained from patient and donor. * Any patient who has undergone allogeneic stem cell transplantation with c GvHD. * Have not received additional agent for cGVHD within 3 months. * Expected life is more than 90 days. * Adequate pulmonary function with no evidence of chronic obstructive or severe restrictive pulmonary disease. * Adequate cardiac function with no evidence of uncontrolled high blood pressure,congestive heart failure, angina pectoris, acute myocardial infarction within 6 months prior to the process. Exclusion Criteria: * Invasive fungal disease. * Active cytomegalovirus (CMV)/Epstein-Barr virus(EBV)/varicella disease). * Patient is with a history of hypersensitivity to bovine products. * Relapsed malignancy.