Development of Countermeasures Against Adverse Metabolic Effects of Shift Work

N/ACompletedNCT02291952

Brigham and Women's Hospital20 enrolled

Overview

The goal of this application is to determine whether changing the timing of food intake prevents the adverse metabolic effects of circadian misalignment.

Shift work is associated with circadian misalignment and an increased risk for the development diabetes, obesity, and cardiovascular disease. This research will determine whether changing the feeding schedule can prevent metabolic alterations that can lead to the abovementioned disorders. This research will provide mechanistic insight and may provide a novel therapeutic approach against the increased risk for diabetes, obesity, and cardiovascular disease among shift workers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Circadian Dysregulation

Interventions

Meal scheduleBEHAVIORAL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 18.5 and 29.9 kgm-2 * Healthy adults with regular sleep-wake timing * Non-smokers * Completion of medical and psychological screening tests * Able to spend 14 consecutive days in the sleep laboratory Exclusion Criteria: * BMI \<18.5 or \> 29.9 kgm-2 * History of neurological or psychiatric disorder * History of sleep disorder or regular use of sleep-promoting medication * Current prescription, herbal, or over-the-counter medication use * Traveling across 2 or more time zones within past 3 months * Donating blood within past 8 weeks * Worked night or rotating shift work within past 3 years * Hearing impairment * Drug or alcohol dependency

Locations (1)

Brigham and Women's Hospital

Boston, Massachusetts, United States