Study to Evaluate Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of GX-E2 in Healthy Subjects

Inclusion Criteria: * Written informed consent * Male subjects 20 to 55 years old * Adequate body weigth and BMI(19 ≤ BMI ≤ 27, 60.0kg ≤ body weigth ≤ 90.0kg) * The subject doesn't have a clinically significant abnormal laboratory value and/or clinically significant unstable medical or disease history. * Are eligible for the study hemoglobin data(12.0g/dL ≤ Hb ≤ 16.5g/dL) (Data is checked per 2 weeks within 28 days) * Adequate transferrin saturation, serum ferritin within 28 days * Adequate folate within 28 days * Adequate vitamin B12 within 28 days * Adequate WBC count (≥ 3.0 X 1000 µL) * Adequate PLT count(≥ 140 X 1000 µL) * nonsmoker or smoker smoked under 10 cigarettes a day Exclusion Criteria: * The subject has a clinically significant abnormal allergy including medical allergy. * The subject has evidence of clinically significant gastrointestinal, cardiovascular, hepatic, renal, hematological, neoplastic, endocrine, neurological, immunodeficiency, pulmonary, or other disorder or disease * Subject with a previous experience in i.v. administration of EPO, darbepoetin, other EPO supplying proteins, immunoglobulin and iron drugs * Subject with a hypersensitivity against EPO, darbepoetin and supplementary iron drugs * Subject with a condition of hemoglobinopathy (e.g. sickle-cell disease and thalassemia) * Subject showing following systolic and diastolic parameters at sitting position after 3 minutes of resting: lower than 90 mmHg or higher than 140mmHg of systolic blood pressure and lower than 50 mmHg or higher than 90mmHg of diastolic blood pressure * Subject with chronic and uncontrollable symptoms of inflammatory disease (e.g. rheumatoid arthritis and systemic lupous erythematousus) * Subject with the exceeding level of C-reactive protein more than 4 mg/dL before 2 weeks of IP administration * History of drug prior to screening or urine drug testing is positive (cocaine, amphetamines, barbiturates, opiates, benzodiazepine, cannabinoids) * Subject who has administered with a prescribed drug and oriental or herbal medicine in 2 weeks before IP administration, and who has administered with a general pharmaceutical and vitamin in 1 week before IP administration * Subject who has enrolled in other clinical trials of IP or approved drug within 8 weeks before IP administration * Subject with a history of fever at body temperature more than 38°C in a week before IP administration * History of epileptic convulsion within 6 months * Subject who is positive in HIV, HBsAg, HCV antibody test * Subject with a regular alcohol consumption more than 21 unit, and who is unable to quit drinking during the period of clinical trial * Subject who donated or lost more than 400mL of blood within 8 weeks prior to first dose * Subject who is treated with investigational products. * Subject with a longer length of spleen more than 16cm via upper abdominal ultrasound during the screening * Subject who is considered as inappropriate for participation by Investigator based on various lab results * Subject who plans to be pregnant or at least is unable to apply authorized contraceptive methods (e.g. sterilization operation, the use of contraceptive devices)