Cardiovascular Benefits of Acai Polyphenols in Volunteers at Risk of Metabolic Syndrome

University of Reading23 enrolled

Overview

The purpose of this study is to carry out a randomized double blind controlled trial in 30 male subjects to investigate the effect of acai consumption on acute changes in vascular function, and to other cardiovascular markers. As a secondary aim the study will allow us to characterize the absorption and metabolism of acai polyphenols in humans over a 24 hour period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Cardiovascular Diseases

Interventions

Acai puree, frozen blended it with bananaDIETARY_SUPPLEMENT

150g of acai fruit, frozen blended it with banana.

Control Macronutrient matchedDIETARY_SUPPLEMENT

Macronutrient matched control in water and also prepared with banana.

Eligibility

Sex: MALEMin age: 30 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male, 30-65 aged, BMI 25-35 kg/m2, Cholesterol \<8 mmol/l. Exclusion Criteria: * Female, BMI \<25 or \>35 kg/m2, Cholesterol \>8mmol l-1, elevated fasting blood sugar \> 6.5 mmols l-1 , elevated systolic blood pressure \>150 mmHg, history of stroke or heart attack within the previous 12 months, current smoking, taking lipid lowering, blood pressure lowering or anti-blood clotting medication or taking micronutrient supplements.

Locations (1)

Hugh Sinclair Unit of Human Nutrition

Reading, Berkshire, United Kingdom

Outcomes

Primary Outcomes

Flow-mediated dilation

Time frame: Change from baseline to 2h

Secondary Outcomes

plasma polyphenol metabolites

Time frame: Change from baseline to 24h

Data from ClinicalTrials.gov

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