Aim: To investigate the dose-dependent vascular effect (primarily using FMD) of 3 low-level doses of pure (-)-epicatechin ≤ 1 mg/kg BW (0.1, 0.5 \& 1.0 mg/kg BW) in healthy men.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
21
Control
EC 0.1 mg/kg
EC 0.5
Department of Food and Nutritional Sciences
Reading, Berkshire, United Kingdom
Flow mediated dilatation
Time frame: baseline to 2h
Laser Doppler Imaging with Iontophoresis
Time frame: baseline to 2h
Plasma (-)-epicatechin metabolites
Time frame: baseline to 24h
Plasma nitrate/nitrite
Time frame: baseline to 2h
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EC 1.0