Evaluate if gene expression changes in SOD2 explain the health benefits of high polyphenols cocoa
Evaluate if gene expression changes in SOD2 explain the health benefits of high polyphenols cocoa.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
50
Cocoa Pure.
Placebo.
Measurement of changes in SOD2 gene expression
Time frame: after acute dose and 4 weeks of chronic dose
Determination of DNA methylation pattern in the chronic phase of the study
Time frame: After 4 weeks of chronic dose
Evaluation of (-)epicatechin bioavailability in plasma
Time frame: After 4 weeks of chronic dose
Determination of plasma antioxidant capacity as a marker of oxidative stress
Time frame: After 4 weeks of chronic dose
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