Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)

Major Inclusion Criteria: 1. DCM with left ventricular ejection fraction (LVEF) ≤ 35% as determined by a historical TTE within the previous 6 months 2. New York Heart Association (NYHA) Class III or ambulatory Class IV heart failure 3. Use of evidence based medical-therapy (beta-blockers, ACE-inhibitors/angiotensin receptor blockers, aldosterone antagonist) and with or without device-therapy (Implantable cardioverter-defibrillator or cardiac resynchronizing therapy), in accordance with the ACC/AHA guidelines for the management of heart failure, for at least three months prior to enrollment or documented contraindication or intolerance or patient preference 4. Coronary anatomy suitable for Investigational Product (IP) infusion, as determined by the Eligibility Committee (a team of cardiology experts) 5. Ability to provide informed consent and follow-up with protocol procedures 6. Screening cardiac CT left ventriculogram ejection fraction \<40% with left ventricular dilatation 7. Age ≥ 18 years Major Exclusion Criteria: 1. Diagnosis of active myocarditis 2. Immunologic incompatibility with all available Master Cell Banks (MCBs) by single-antigen bead (SAB) serum antibody profiling 3. Left Ventricular Assist Devices (LVAD) or those actively in the process of acquiring one 4. Recent placement of a cardiac pacemaker and/or resynchronization pacing therapy within the past three months or those actively in the process of acquiring one 5. History of sustained ventricular tachycardia (VT) requiring cardiopulmonary resuscitation (with the exception of subjects who subsequently received an ICD) 6. Non-cardiovascular disease with life expectancy of \< 3 years 7. Known hypersensitivity to contrast agents 8. Estimated glomerular filtration rate (GFR) \< 50 mL/min 9. Active infection not responsive to treatment 10. Active allergic reactions, connective tissue disease or autoimmune disorders 11. History of cardiac tumor, or cardiac tumor demonstrated on screening 12. History of previous stem cell therapy 13. History of treatment with immunosuppressive agents, including chronic systemic corticosteroids, biologic agents targeting the immune system, anti-tumor and anti-neoplastic drugs or anti-vascular endothelial growth factor (VEGF) within 6 months prior to enrollment (not including drug eluting coronary stents) 14. History of receipt of chemotherapeutic agents known to be implicated in cardiac dysfunction \[Adriamycin, trastuzumab (Herceptin)\] 15. Known moderate-severe aortic stenosis/insufficiency or severe mitral stenosis/regurgitation 16. Participation in an on-going protocol studying an experimental drug or device 17. Current active alcohol or drug abuse or inability to comply with protocol-related procedures 18. Pregnant/nursing women and women of child-bearing potential without use of active and highly reliable contraception 19. Known history of Human Immunodeficiency Virus (HIV) infection 20. Known history of chronic viral hepatitis 21. Abnormal liver function (serum glutamic pyruvic transaminase (SGPT) \> 10 times the upper reference range) and/or abnormal hematology (hematocrit \< 25%, white blood cells (WBC) \< 3000 µl, platelets \< 100,000 µl) studies without a reversible, identifiable cause 22. Evidence of tumor on screening of chest/abdominal/pelvic (body) CT scan 23. Any prior organ transplant 24. Being actively listed for, or under active consideration (i.e., work-up) for, a solid organ transplant of any kind 25. Known hypersensitivity to bovine products 26. Known hypersensitivity to dimethyl sulfoxide (DMSO) 27. Any malignancy within past 2 years (except for in-situ non-melanoma skin cancer and in-situ cervical cancer) 28. Any prior radiation therapy/treatment to the chest 29. Uncontrolled diabetes (HbA1 \>9.0) 30. Any condition or other reason that, in the opinion of the Investigator or Medical Monitor, would render the subject unsuitable for the study