Renal Sympathetic Denervation by Iberis System in Patients With Uncontrolled Hypertension - Iberis-HTN Registry

Inclusion Criteria: * Age ≥18 years or minimum age as required by local regulations. * Patient has been thoroughly informed about this registry and signed Informed Consent Form. * Patient with true resistant hypertension defined as: * Office systolic BP higher than 160 or 150mmHg in case of type 2 diabetes * Ambulatory BP with average BP\>130mmHg or mean daytime\>135mmHg in more than 70% of the measurements. * Patients should be on stable hypertension therapy for at least 8 weeks before procedure, including spironolactone if they are supposed to be respondent as indicated by the specialized center/excellence unit on hypertension. Exclusion Criteria: * Previous renal artery intervention (balloon angioplasty or stenting). * Evidence of renal artery atherosclerosis (defined as a renal artery stenosis \>50%). * Main renal arteries of less than 4mm diameter or less than 20mm in length. * Presence of multiple main renal arteries in either kidney. * Estimated glomerular filtration rate \<45ml/min per 1,73m2 * Recent myocardial infarction, unstable angina pectoris or cerebrovascular accident within the past 3-6 months. * False resistant hypertension (pseudo resistance) by using 24h ambulatory BP monitoring (ABPM). * Secondary arterial hypertension. * Pregnancy. * There is another pathological process with well-known life expectancy of less than 5 years. * Patient unable to do correct FU. * Unable to take correct ambulatory BP. * Primary hyperaldosteronism. * Known lack of adherence to medical treatment.