Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy

Inclusion Criteria: 1. Age between 18\~70,both gender. 2. Patients with upper gastrointestinal symptoms and with documented H.pylori infection. 3. Patients are willing to receive eradication treatment. 4. Women are eligible if they are not pregnant or nursing, and if they are of childbearing potential they are required to use medically acceptable contraception for the duration of the study and 30 days thereafter. Exclusion Criteria: 1. Patients are excluded if they have previously used antibiotics to eradicate adequately recorded infection with H. pylori. 2. Contraindications to study drugs. 3. Substantial organ impairment, severe or unstable cardiopulmonary or endocrine disease. 4. Constant use of anti-ulcer drugs ( including taking proton-pump. inhibitors(PPI) within 2 weeks before the \[13C\] urea breath test), antibiotics or bismuth complexes (more than 3 times /1 month before screening) 5. Pregnant or lactating women. 6. Underwent upper gastrointestinal Surgery. 7. Patients with Barrett esophageal or highly atypical hyperplasia, have symptom of dysphagia. 8. Evidence of bleeding or iron eficiency anemia. 9. A history of malignancy. 10. Drug or alcohol abuse history in the past 1 year. 11. Systemic use of corticosteroids, non steroidal anti-inflammatory drugs, anticoagulants, platelet aggregation inhibitors (except the use of aspirin for less than 100 mg/d). 12. Enrolled in other clinical trials in the past 3 months.