Late Effects of Radiosurgery on Acromegaly Study

Inclusion Criteria: * Subject, man or woman, whose age is greater than or equal to 18 years; * Subject has a combination of defined values plus Insulin Like Growth Factor-1 and no braking growth hormone (\<1.2 milli-International unit/L) during an oral glucose tolerance acromegaly. * Exposed: Subject with a surgically treated in remission with or without drug treatment somatostatinergic, acromegaly who received treatment with Gamma Knife radiosurgery within not less than 10 years and less than or equal to 20 years. * Not exposed: Subject with a surgically treated acromegaly controlled by treatment somatostatinergic, not having received Gamma Knife radiosurgery. * Subjects with thyroid under standardized assessment Levothyrox® inclusion in case of deficit associated thyroid stimulating; * Topic supported in a project partner services; * Subjects who have signed a written informed consent and agreeing to abide by the instructions of the protocol. Exclusion Criteria: * Minor or over the age of 75 years subject, * Subjects with acromegaly resistant to somatostatinergic, or that required power is pegvisomant or cabergoline * Subjects who received two pituitary neurosurgical treatment or treatment with conventional radiotherapy or radiosurgery treatments 2 * Pregnant or lactating woman, * Topic is not affiliated with the social security system, or private about freedom; * Subject refusing to participate in the study or not signing the informed consent; * Subject with malignant disease known evolutionary