Intravesicular Onabotulinumtoxin A in Interstitial Cystitis

Inclusion Criteria: 1. Adult females between the ages of 18 and 80 inclusive 2. Patients being treated for IC who are refractory to conservative management and oral therapy. 3. willing and able to initiate catheterization post-treatment Exclusion Criteria: 1. Any history of bladder cancer, uterine cancer, ovarian cancer, vaginal cancer, urethral diverticulum, spinal cord injury, stroke, Parkinson's disease, multiple sclerosis, spina bifida, cyclophosphamide treatment, radiation treatment to the pelvis, bladder tuberculosis, genital herpes. 2. Currently on or requiring anti-platelet/anti-coagulant concomitant therapy or having been on anti-platelet/ anti-coagulant therapy within the past 3 months 3. Pregnancy. Pregnancy is an absolute contraindication to undergoing these procedures. Thus, as part of their normal pre-operative work up, which is standard of care, pregnancy tests are administered if they are women of child-bearing age, are sexually active, and are within 10 days of the normal menstrual period. If positive, they will be excluded as they will not undergo the procedure. 4. An active urinary tract infection as shown during clean-catch urinalysis at screening visit. Subject may be re-screened if UTI is successfully treated and urinalysis is negative at rescreening. 5. A history of hypersensitivity or allergy to any botulinum toxin preparation 6. A post-void residual (PVR) urine volume \>200mL at baseline 7. Treatment with botulinum toxin during the 12 week period prior to the trial