This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.
Reactive oxygen metabolites (reactive oxygen metabolites, ROMs) test is a method by measuring the total reactive oxygen metabolites (ROMs) content in blood so as to evaluate the overall level of oxidative stress in the human body .Our previous studies have established the method of detecting ROMs which is suitable for fully automatic biochemical analyser.Our study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.
Study Type
OBSERVATIONAL
Enrollment
320
Respiratory Institute;Beijing chaoyang hospital
Beijing, Beijing Municipality, China
RECRUITINGThe different levels of the ROMs among different groups
Apply the analysis of variance to compare the different levels of ROMs among the four different groups
Time frame: 3 years
The differences of the ROMs among the different lung function levels in the stable stage of COPD group
Apply the analysis of variance to compare the differences of the ROMs among the lung function levels in the stable stage of COPD group.
Time frame: 3 years
The relevance of the ROMs with the lung function levels in the stable stage of COPD group
Apply Pearson correlation to compare relevance the of the ROMs with the lung function levels in the stable stage of COPD group.
Time frame: 3 years
The relevance of the ROMs with the score of mMRC in the stable stage of COPD group
Apply Pearson correlation to compare relevance the of the ROMs with score of mMRC in the stable stage of COPD group.
Time frame: 3 years
The relevance of the ROMs with the score of CAT in the stable stage of COPD group
Apply Pearson correlation to compare relevance the of the ROMs with score of CAT in the stable stage of COPD group.
Time frame: 3 years
The relevance of the ROMs with the numbers of exacerbation in the stable stage of COPD group
Apply Pearson correlation to compare relevance the of the ROMs with numbers of exacerbation in the stable stage of COPD group.
Time frame: 3 years
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