The purpose of this study is to evaluate the efficacy of low dose quetiapine for the prophylaxis of delirium in critically ill patients in medical intensive care unit.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
194
patient body weight \<50kg : quetiapine 12.5mg patient body weight \>=50kg : quetiapine 25mg quetiapine 12.5mg (bwt \<50kg ) or 25mg (bwt\>= 50kg) study medicine is pulverized to power and melted in 10cc tepid water. The study medicine(quetiapine) will be provided as liquid form. The study medicine(quetiapine) was provided as liquid form (medicine was pulverized and melted in 10cc water).
The placebo is made of 100mg of corn starch which is melted in 10cc water.
Development of delirium within 14 days after admitting to ICU (Rate)
Time frame: 14 days after admitting to intensive care unit
Duration of delirium occurring within 14 days after admitting to ICU (Days)
Time frame: 14 days after admitting to ICU
Length of stay in ICU and hospital (Days)
Time frame: up to 24 weeks
60 days in hospital mortality (Rate)
Time frame: 60 days after admitting to ICU
Duration of mechanical ventilation in ICU (Days)
Time frame: 14days after admitting to intensive care unit
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