Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome

Inclusion Criteria: 1\. Patients with endogenous Cushing's syndrome: * Cushing disease patients with persistent or recurrent disease (after pituitary surgery) or who are newly diagnosed but are unsuitable for early surgery or wish to defer surgery; * Patients with ectopic ACTH syndrome (either occult, after surgery failure, or inoperable or metastatic); * Patients with Cushing's syndrome from adrenal causes Exclusion Criteria: 1. Pseudo Cushing's syndrome 2. Cyclic Cushing's syndrome defined by at least one normal UFC value among at least three 24-hour urinary sampling measurements over the previous 2 months 3. Advanced adrenocortical carcinoma or ectopic ACTH secretion (EAS) secondary to a small cell lung carcinoma 4. Life expectancy less than 3 months 5. Pituitary or adrenal surgery or pituitary irradiation or surgery of the ACTH-secreting ectopic tumor or bilateral adrenalectomy planned before the week 12 visit 6. Pituitary irradiation within the previous 5 years (for Cushing's disease patients) 7. Enlarged pituitary adenoma (greater than 1 cm in vertical diameter and leaving less than 2 mm from the chiasma) or compression of the optic chiasma on the pituitary MRI for patients with Cushing's disease 8. Severe uncontrolled hypertension (\>180/110 mmHg) despite anti-hypertensive therapy (for otherwise eligible patients, blood pressure medication may be adjusted to meet this criterion) 9. Severe hypokalemia (\< 2.5 mmol/L) despite corrective measures 10. White blood cell counts \<3 x 109 /L; hemoglobin \<10 g/dL; platelets \<100 x 109 /L 11. Any other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that in the judgment of the investigator, would present excess risk associated with study participation or study drug administration, or which, in the judgment of the investigator, would make the patient inappropriate for entry into this study.