To describe the effectiveness of angiotensin-converting enzyme inhibitor and non-dihydropyridine calcium channel blocker single pill combination on systolic blood pressure (SBP) lowering in hypertensive patients with elevated heart rate and type 2 diabetes
Study Type
OBSERVATIONAL
Enrollment
270
Research facility ID ORG-001108
Adana, Turkey (Türkiye)
Absolute change in systolic blood pressure
mmHg
Time frame: from baseline to week 8
Absolute change in diastolic blood pressure (DBP)
mmHg
Time frame: from baseline to week 8
Ratio of patients achieving blood pressure ≤ 140 and/or 90 mmHg
Time frame: from baseline to week 8
Ratio of responder patients (reduction of SBP ≥20 mmHg and/or DBP ≥10 mmHg)
Time frame: from baseline to week 8
Absolute change of heart rate
beat/min
Time frame: from baseline to week 8
Correlation between absolute change in blood pressure and absolute change in heart rate
Time frame: from baseline to week 8
The absolute change in PR interval on electrocardiography
ms. The PR interval indicates "atrioventricular conduction time".
Time frame: from baseline to week 8
The absolute change in HbA1c (if available)
Time frame: from baseline to week 8
The absolute change in microalbuminuria (if available)
mg/mmol
Time frame: from baseline to week 8
The ratio of patients experiencing an adverse event including the nature of the adverse event/severe adverse event
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Research facility ID ORG-001030
Ankara, Turkey (Türkiye)
Yıldırım Beyazıt University Yenimahalle Training and Research Hospital
Ankara, Turkey (Türkiye)
Research facility ID ORG-001111
Antalya, Turkey (Türkiye)
Research facility ID ORG-001120
Aydin, Turkey (Türkiye)
Research facility ID ORG-001119
Aydin, Turkey (Türkiye)
Research facility ID ORG-001116
Balıkesir, Turkey (Türkiye)
Research facility ID ORG-001112
Burdur, Turkey (Türkiye)
Research facility ID ORG-001123
Çorum, Turkey (Türkiye)
Erzurum Regional Training and Research Hospital
Erzurum, Turkey (Türkiye)
...and 13 more locations
Time frame: from baseline to week 8
The correlation between physician's office and home blood pressure measurements (Difference in medians)
mmHg
Time frame: from baseline to week 8
Blood pressure variability (daily or hourly) in home blood pressure measurement
Time frame: from baseline to week 8