The purpose of this study is to compare the effect of valsartan and perindopril on HOMA-IR Index in patients with chronic kidney disease.
eligiable volunteers are administrated single-dose over the period I and II (crossover) of Valsartan (80mg) as of Perindopril (4mg). Every time before and after each medication, HOMA-IR index and other parameters and safety of Valsartan (80mg) and Perindopril (4mg) is performed using a blood sample and conducting some tests (vital signs, physical exam, ECG, laboratory test, etc.) respectively.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Valsartan 80mg/tablet, 1 tablet once daily (crossover)
Perindopril 4mg/tablet, 1 tablet once daily (crossover)
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Homeostasis model of assessment for insulin resistence index (HOMA-IR index)
HOMA-IR=FINS\*FGLU/22.5
Time frame: 4 weeks
Glomerular filtration rate(eGFR) and Creatinine clearance rate(CCR)
eGFR and CCR are calculated with MDRD formula
Time frame: 4 weeks
Body mass index(BMI)
BMI=weight/(height)\^2
Time frame: 4 weeks
24-h urine protein, urinary albumin-creatinin ration, retinol binding protein
Time frame: 4 weeks
Cholesterol, triglycerides, high density lipoprotein, low density lipoprotein
Time frame: 4 weeks
Glycosylated hemoglobin
Time frame: 4 weeks
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