Clinical Study of POSS-PCU Vascular Grafts for Vascular Access

Inclusion Criteria: * Subjects requiring vascular access for haemodialysis * Subjects with no suitable vein. * Subjects aged 18 - 80 years old * Subjects are able to give voluntary, written informed consent to participate in this clinical investigation and from whom consent has been obtained * Patients of child bearing potential, who are sexually active, must agree to the use of 2 highly effective forms of contraception throughout their participation in the study and for 6 months after completion of treatment: * Condom with spermicide. AND 1 of the following: * Oral contraceptive or hormonal therapy (e.g. hormone implants). * Placement of an intra-uterine device. Exclusion Criteria: * Subjects with predicted short-term survival (less than 18 months) or poor prognosis (this will be on the discretion of the clinician in charge) * Subjects with left ventricle ejection fraction (LVEF) \<20% diagnosed on ECHO either pre-procedure or documented within the previous 3 months prior to consent. * Pregnant or lactating * Allergies to any constituents of the graft material * Patients who are infected or colonized with Methicillin Resistant Staphylococcus Aureus (MRSA).