Aggressive Onset Multiple Sclerosis: A Practical Definition and Study of Its Clinical Course

Weill Medical College of Cornell University750 enrolled

Overview

Chart review.

A chart review will be completed on patients with multiple sclerosis to determine potential early characteristics that might be helpful in defining aggressive onset MS and predicting subsequent disease course and disability

Study Type

OBSERVATIONAL

Enrollment

750

Conditions

Multiple Sclerosis

Eligibility

Sex: ALLMin age: 0 YearsMax age: 89 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Two or more relapses in the preceding year and 2 or more gadolinium enhancing lesions on brain MRI scan or a significant T 2 lesion burden or * One relapse if it results in sustained EDSS of 3.0 along with 2 or more gadolinium enhancing lesions or significant T2 lesion burden ( T2 lesion burden being determined by factoring the number of lesions, the size of the lesions and lesion location) Exclusion Criteria: \-

Locations (1)

Weill Cornell Medical College

New York, New York, United States

Outcomes

Primary Outcomes

Disability outcome will be determined based on EDDS.

Disability outcomes will be determined based on EDDS at last visit. EDSS at last follow up will be compared to EDSS at start of respective therapies and grouped into 3 categories: EDSS improved, EDSS no change and EDSS worsened. Multivariate logistic regression will be used to test individual variables that could potentially influence the outcome, including treatment, age at onset, gender and race.

Time frame: at the last visit (average time frame from baseline to last follow up visit expected to be 36 months)

Data from ClinicalTrials.gov

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