Dose Escalation Study of AST-OPC1 in Spinal Cord Injury

Major Inclusion Criteria: * Sensorimotor complete, traumatic SCI (ASIA Impairment Scale A) for cohorts 1,2,3 * Sensorimotor incomplete, traumatic SCI (ASIA Impairment Scale B) for cohorts 4,5 * Last fully preserved single neurological level (SNL) from C-4 to C-7 * From 18 through 69 years of age at time of injury * Single spinal cord lesion on a post-stabilization magnetic resonance imaging (MRI) scan, with sufficient visualization of the spinal cord injury epicenter and lesion margins to enable post-injection safety monitoring * Informed consent for this protocol and the companion long term follow-up protocol must be provided and documented (i.e., signed informed consent forms) no later than 37 days following injury * Able to participate in an elective surgical procedure to inject AST-OPC1 21-42 days following SCI Major Exclusion Criteria: * SCI due to penetrating trauma * Traumatic anatomical transection or laceration of the spinal cord based on prior surgery or MRI * Any concomitant injury that interferes with the performance, interpretation or validity of neurological examinations * Inability to communicate effectively with neurological examiner such that the validity of patient data could be compromised * Significant organ damage or systemic disease that would create an unacceptable risk for surgery or immunosuppression * History of any malignancy (except non-melanoma skin cancers) * Pregnant or nursing women * Body mass index (BMI) \> 35 or weight \> 300 lbs. * Active participation in another experimental procedure/intervention