Dyad Oxytocin Study (DOS)

Inclusion Criteria: * Inclusion criteria for caregiver of patients with schizophrenia, patients with autism spectrum disorder, and healthy controls: * Age between 18 and 75 years old * Must have at least 4 hours of contact with the patient per week and be considered a "significant caregiver" by the patient Inclusion criteria for patients with schizophrenia: * Between the ages of 14 and 45. * Patients must have a diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder or psychosis- Not Otherwise Specified (NOS). * Patients must be clinically stable * No or minor changes to medications in the past week * Patients must have a primary caregiver * Inclusion criteria for healthy control child: * Between the ages of 14 and 45 * Healthy control must have a primary caregiver * Inclusion criteria for patients with autism spectrum disorder * Between the ages of 14 and 45 * Patient must have a primary caregiver * Patients must have a diagnosis of an autism spectrum disorder (ASD) (autism or Asperger's disorder), pervasive developmental disorder (PDD) or pervasive developmental disorder - not otherwise specified (PDD-NOS). Exclusion Criteria: Exclusion criteria for all caregivers: * Female caregivers that state that they are pregnant or have a positive urine pregnancy test * Caregivers who have significant nasal pathology, atrophic rhinitis, recurrent nose bleeds, or history of cranial-surgical procedures (hypophysectomy) * Caregivers with significant psychiatric, neurologic, or medical illness * Exclusion criteria for healthy controls: * Healthy controls with history of psychiatric or neurological illness * Exclusion criteria for patients with an autism spectrum disorder: * Patients with an Intelligence Quotient (IQ) lower than 75 * Exclusion criteria for patients with schizophrenia * Patients with severe brain trauma