Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)

University Hospital, Tours16 enrolled

Overview

Adolescent idiopathic scoliosis (AIS) is a complex deformity with different curves. These different curves may be distinguished by different physiopathologic mechanisms. Without fully convincing model of the emergence and development of AIS, their multifactorial nature seems evident. Several pathophysiological theories involving the central nervous system have been proposed: the AIS would be associated with disturbances of proprioceptive or sensory perception, and/or with integration of this information. This would result in an abnormal body image, responsible for sensorimotor asymmetry that may promote or cause the deformation. The Main aim of this study is to find cortical and subcortical morphometric differences in the most common population of AIS (right thoracic AIS) compared to healthy adolescent control girls. Secondary Objectives are to study the cerebral white matter of the same groups (fractional anisotropy in the main white matter tracts), and activation of sensorimotor neural networks (fMRI activation and functional brain connectivity). Abnormalities of the studied parameters may be used as biomarkers for AIS diagnosis and classification.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Adolescent Idiopathic Scoliosis

Interventions

Eligibility

Sex: FEMALEMin age: 14 YearsMax age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * female * between 14 and 16 years old * normal neurological examination * right handed * informed consent * informed consent form signed by a parent or a holder of parental authority * affiliated to medical insurance * negative urine pregnancy test For patients (A-STD) : right thoracic scoliosis with a Cobb angle between 20 and 40° For healthy volunteers (A-N) : no clinical scoliosis Exclusion Criteria: * pregnant or lactating woman * antecedents of cranial trauma or cranial intervention, of migraine, of spinal trauma, of scoliosis intervention * no idiopathic scoliosis * contraindications to MRI * patient with a legal protection measure

Outcomes

Primary Outcomes

Variation in regional cortical and subcortical volume, as measured by MRI

Time frame: One day

Secondary Outcomes

Variation in fractional anisotropy in the main white matter tracts, as measured by MRI

Time frame: one day

Variation in activation of sensorimotor neural networks, as measured by MRI