In animals, treatment with vitamin B3 improved insulin sensitivity and substrate metabolism. It is currently not know if vitamin B3 has the same positive effects in humans. In the current study the effect of a 3 month treatment with vitamin B3 on insulin sensitivity and substrate metabolism in obese men will be investigated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
Medical Research Laboratories, Aarhus University Hospital
Aarhus, Denmark
Insulin sensitivity
determined by a hyperinsulineamic clamp
Time frame: Change from baseline in insulin sensitivity at 3 months
Substrate metabolism
measured by indirect calorimetry
Time frame: Change from baseline in substrate metabolism at 3 months
body composition
measured by DEXA scan
Time frame: Change from baseline in body composition at 3 months
Activation of satellite cells
measured by immunohistochemestry
Time frame: Change from baseline in activation of satellite cells at 3 months
lipid accumulation in liver and skeletal muscle tissue
determined by MR-spectroscopy
Time frame: Change from baseline in liver and muscle lipid content at 3 months
glucose turnover
determined by glucose tracer techniques
Time frame: Change from baseline in glucose turnover at 3 months
insulin signalling in skeletal muscle and adipose tissue biopsies
western blotting
Time frame: Change from baseline in insulin signaling at 3 months
Palmitate turnover
determined by palmitate tracer techniques
Time frame: Change from baseline in palmitate turnover at 3 months
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Gut microbiota
Intestinal bacteria composition by whole genome sequencing
Time frame: Change from baseline in composition of gut microbiota at 3 months
Incretin hormone secretion
Determined by measurement of incretin homones during an oral glucose tolerance test (OGTT)
Time frame: Change from baseline in incretion hormone secretion at 3 months