This study evaluates the long-term safety of Udenafil in Patient with Pulmonary Arterial Hypertension(PAH). All the patients will receive Udenafil for 1-year(48-weeks).
Pulmonary arterial Hypertension is characterized by a progressive incerease in pulmonary vascular resistance(PVR) leading to right ventricualar failure. Udenafil inhibits PDE 5, an enzyme that metabolizes cGMP, enhancing the cGMP mediated relaxation and growth inhibition of vascular smooth muscle cells, including those in the lung.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
59
Udenafil 50mg tablet
Samsung Medical Center
Seoul, Gangnam-Gu, Irwon-Dong 50, South Korea
Safety (Adverse Events, Physical Examination, Vital Sign, Electrocardiography, Laboratory test, etc)
Adverse Events, Physical Examination, Vital Sign, Electrocardiography, Laboratory test, etc
Time frame: during 48-weeks
6-MWD
Time frame: 24, 48-week
BORG dyspnea score
Time frame: 24, 48-week
WHO class
Time frame: 12, 24, 36, 48-week
Time to clinical worsening(TTCW)
Time frame: during 48-weeks
NT-pro BNP
Time frame: 24, 48-week
Echocardiography
Time frame: 48-week
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