Effect of Glucosamine on Intraocular Pressure

Shahid Beheshti University of Medical Sciences41 enrolled

Overview

In this double blind clinical trial 92 patients suffering from rheumatoid arthritis are included. Those with the history of intraocular and corneal surgery, diabetic and heavy smokers are excluded from the study. Before starting the treatment all patients undergo complete ophthalmic exam, corneal biomechanical properties assessment by Ocular Response Analyzer (ORA) and corneal thickness measurement. Patients are randomly assigned to treatment and placebo groups. Those in the treatment groups receive glucosamine sulfate 1500 mg three times a day. Those in placebo arm receive alike capsule with the same schedule. At month 3 and 6 IOP(intraocular pressure), ORA and pachymetry would be checked again.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Intraocular Pressure Changes After Glucosamine Sulfate Consumption.

Interventions

Eligibility

Sex: ALLMin age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * History of rheumatoid arthritis based on ACR (American College of Rheumatology)FC(functional classes). * No history of using drugs tested in the study. Exclusion Criteria: * History of any kind of corneal surgery. * History of intraocular surgery. * History of diabetes mellitus. * Heavy smokers. * Unwillingness to participate in the study.

Outcomes

Primary Outcomes

Intraocular pressure changes

: Goldmann applanation tonometry

Time frame: until 6 months

Secondary Outcomes

corneal biomechanical changes

Ocular Response Analyzer (ORA)