The purpose of this study is to determine whether edometrial local injury improves the outcome of embryo transfer,and to find out more evidence about the time of trauma,the way of intervention,and the possible mechanism.
It is important to evaluate the efficacy of endometrial local injury in assisted reproductive technology(ART),especially on the patients of recurrent implantation failure. Although most trials proved the effectiveness of the intervention of local injury, the subjects of these trials are rarely the patients of repeated implantation failure(RIF). Moreover, the mechanism of endometrial injury is not clear.Our trial may provide further basis for this purpose by comparing to the quality of endometrium in two-dimensional ultrasound.If the technique demonstrates efficacy, it would help the patients with RIF caused by poor conditions of endometrium to deal with the problem of infertility.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
The way of intervention is to scratch the uterine cavity two cycles by a small spatula in the first 3-5 days after menstrual period.
Department of Obstetrics and Gynecology, Navy General Hospital.
Beijing, Beijing Municipality, China
RECRUITINGimplantation rate
When serum HCG is continuously more than 100mIU/ml and gestational sac is detected by ultrasound,it is considered as implantation.
Time frame: 3 months after intervention
the change of three-dimensional ultrasound of uterine cavity before and after intervention
including endometrial thickness, echo, blood flow and uterine cavity volume, uterine vascularization index, flow index.
Time frame: in implantation window period(12-14 days)
clinical pregnancy rate
The standards is to detect fetal heart beat by ultrasound.
Time frame: an expected average of 7 week after pregnancy
live birth rate
The statistical ratio of live birth rate in two groups
Time frame: follow-up for one year after pregnancy
the rate of birth defects
calculate the rate of birth defects in two groups
Time frame: follow-up for one year after pregnancy
the expression changes of endometrial inflammatory factors
Detection of inflammatory factors, such as LIF,MIP-1. \---------------------------
Time frame: endometrial sampling after local injury ,in the first 3-5 days after menstrual period
infection rate
detection of infection by serum test
Time frame: one week after intervention
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