The purpose of this study is to learn more about how to identify signs of early chronic kidney diseases in children who were born prematurely with low birth weight (less than 3 ½ pounds). Researchers plan to compare the kidney function in children who experienced acute kidney injury (AKI) in the Neonatal Intensive Care Unit (NICU) with those who did not experience it. Evidence from several studies and our experience at UVA show that older children who experienced AKI while in the Pediatric Intensive Care Unit (PICU) have increased risk of developing early chronic kidney disease, and they also show early changes in the urine and blood that is consistent with early chronic kidney disease. In this study, the investigators hope to determine if any of these changes can be detected in early childhood, and if so, at what age we can start detecting these changes.
Study Type
OBSERVATIONAL
Enrollment
80
University of Virginia
Charlottesville, Virginia, United States
RECRUITINGComposite Abnormality
Either eGFR \> 90, urine protein/creatinine \> 0.2, or BP \> 95th percentile for age and height
Time frame: Age 2-7 years
Growth
Evaluation of height, weight and BMI
Time frame: Age 2-6 years
Kidney Size
Evaluation of kidney size
Time frame: Age 2-6 years
Urinary Biomarkers
Evaluation of urine for biomarkers which can be used to detect early chronic kidney disease
Time frame: Age 2-6 years
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