Oral Administration of Colostrum to Premature Babies: Impact on the Oral Microbiota

University of California, Davis12 enrolled

Overview

Oropharyngeal administration of mother's colostrum to premature infants has been proposed as a stimulus to the oropharyngeal lymphatic tissues to decrease the incidence of pneumonia and sepsis, particularly in intubated babies. We propose to study the impact of this intervention on the composition of the oral microbiota.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Changes in the Oral Microbiota

Interventions

ColostrumOTHER

Mother's own colostrum (0.2 ml) will be administered into the mouth of the infant every 2 hours for 48 hours.

Eligibility

Sex: ALLMin age: 12 HoursMax age: 7 Days

Medical Language ↔ Plain English

Inclusion Criteria: * premature infant with birth weight \< 1500 * intubated in the first 48 hours of life * available maternal colostrum Exclusion Criteria: * lethal condition

Locations (1)

UC Davis Children's Hospital

Sacramento, California, United States

Outcomes

Primary Outcomes

Oral microbiota

Changes in the composition of the community of microbes inhabiting the oral-cavity after administration of oropharyngeal maternal colostrum.

Time frame: Difference between enrollment, 48 hours and 96 hours

Data from ClinicalTrials.gov

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