The investigators hypothesize that Nigella Sativa will have an effect on Nonalcoholic Steatohepatitis and Liver Steatosis by enhancing lipophagy in the liver tissue.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
100
Capsules that contain a placebo but look like the Nigella Sativa capsules
Hillel Yaffe Medical Center
Hadera, Israel
Effect of Nigella Sativa on Liver Triglyceride Concentration
The difference in change in the average liver triglyceride concentration will be measured by MRI Spectroscopy between the Nigella Sativa arm and the placebo arm, at start and end of the study.
Time frame: One year
Effect of Nigella Sativa on Improvement in NASH Activity Index
Improvement in Nash activity Index will be measured by the NAFLD Activity Score.
Time frame: One year
Effect of Nigella Sativa on Fibrosis Staging
Microscopic examination of two liver biopsies at start and end of the study, to determine fibrosis staging.
Time frame: One year
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