Pilot Study of the Effectiveness of Probiotics and Lactitol for the Decolonization of OXA-48 (Carbapenemase) Producing Klebsiella Pneumoniae Among Rectal Carriers

Inclusion Criteria: * Men and women over 18 years old * Have signed the informed consent to participate. * Have evidence of intestinal colonization by KP-OXA-48 during the period of screening. * Start of intestinal colonization by KP-OXA-48, \> 6 months of starting treatment. * Absence of exclusion criteria Exclusion Criteria: * Be hospitalized for an acute process at the time of inclusion. * Take antibiotics (oral , intramuscular or intravenous ) at the time of inclusion. * Having diarrhea in the two weeks prior to the inclusion. * Baseline electrolyte abnormalities requiring supplementation : Hypokalemia (K \<3 mEq / L), hypomagnesemia (Mg \<1.8 mEq / L ), hypocalcemia (Ca \< 8mg/dL ) * Suffering from digestive diseases : Crohn's disease, ulcerative colitis , celiac disease, irritable bowel syndrome , intestinal resection, colostomies. * Neutropenia ( neutrophil count \< 1.00 x 10 3 / uL ) or other situations of severe immunosuppression , including continued use of systemic steroids (at least 1mg/kg/day of prednisone or equivalent for more than 1 month) and other forms of pharmacological immunosuppression deemed by the investigator. * Diabetes mellitus poorly controlled ( HgA1c \> 8 mmol / mol ). * Taking antisecretory inhibitors, proton pump or anti -H2. * Advanced chronic renal failure (GFR \< 30 ml / min) * Being a carrier of endovascular prosthetic devices, including long-term central catheters. * Having significant valvulopathy on the opinion of the investigator. * Surgical intervention of gastrointestinal tract in the last three months. * Treatment with systemic corticosteroids or immunosuppressive. * Allergy or intolerance to lactose or lactitol or Infloran .