Disruption of Circadian Rhythm and Healthcare-related Infection in Patients With Severe Trauma

Assistance Publique Hopitaux De Marseille40 enrolled

Overview

Circadian rhythms, which play crucial roles in physiology, are emerging as important regulators of specific immune functions. Hospitalization in intensive care unit leads to a deep impairment of circadian rhythm. Infection is a frequent event during ICU hospitalization. The investigators hypothesis is that in trauma patients the lack of circadian rhythm variations is associated with the occurrence of infection. The primary aim of the study is to assess the circadian variations of plasma Bmal1 in the occurrence of healthcare related infection during the 30 days after inclusion. The secondary aims are to assess the plasma expression of circadian genes (Clock, Cry1, Per3, and Rev-erba), the production of cytokines in plasma, and the concentration of cortisol, according to the occurrence of an infection.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Infection

Interventions

Blood samples will be collected every 4 hours during 24 h

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Trauma patients with an injury severity score \> 15, requiring mechanical ventilation for at least 24 h during the first 48 h and an arterial catheter. Exclusion Criteria: * Pregnant and lactating women

Locations (1)

Assistance Publique Hôpitaux de Marseille

Marseille, France

Outcomes

Primary Outcomes

area under the curve representing the maximal expression of Bmal1 gene during the first 24 h following inclusion

Time frame: 24 hours

Data from ClinicalTrials.gov

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