Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH

Inclusion Criteria: * Male subjects aged 20\~35. * They accorded with diagnostic criteria of severe oligospermia or azoospermia. * They had'nt been treated with drug which could improve sperm count and quality one month before observation，otherwise,they should have a elution for 1 month before the study. Exclusion Criteria: * Gram-positive bacteria ,Chlamydia trachomatis,Ureaplasmaurealyticum,or mycoplasma hominis were detected in their semen. * Subjects addicted to drug，tobacco，or alcohol. * Subjects had heat,chemicals,radioactive material,or toxic contact history within a year. * Subjects were under treatment of gonadotropin,anabolic steroid,chemotherapeutic drugs,or nonsteroidal anti-inflammatory drugs . * Subjects combined with cardiovascular, liver, kidney ,or hematopoietic system severe primary disease,or mental disease. * Subjects were allergic or on uFSH allergy,or under the treatment of other drugs for infertility . * Subjects did not meet the inclusion criteria, did not according to the prescribed medication, were unable to judge the efficacy ,had incomplete information, or affected the efficacy or safety judgment. * Subjects were IHH patients